What is Matlacha Isles like?

Travelers will be sure to find plenty to entertain them in Cape Coral's Matlacha Isles neighborhood.

How many hotels will I be able to find in the Matlacha Isles area?

When you want to kick up your feet after a day of exploring the sights in Cape Coral, you can choose from 18 Expedia hotels and other accommodations in Matlacha Isles.

If I need to cancel my hotel reservation in Matlacha Isles, will I receive a refund?

Yes, you'll find most hotel room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, it may still be possible to cancel it and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the best deals available in Matlacha Isles.

What are the top things to see and do in Matlacha Isles?

A few places to visit in the area around Matlacha Isles include Griffen American Center for Haitian Art, Lovegrove Gallery & Gardens, and Cape Royal Golf Club. While you're out sightseeing in Cape Coral, be sure to visit other sights like Little Dead Key or Big Dead Key.

10 Best Hotels in Matlacha Isles, Cape Coral for 2026

An aerial view of a coastal town with a marina, surrounded by water and green land.

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Our top choices for Matlacha Isles hotels

A beachside area with colorful Adirondack chairs, a fire pit, and a view of the water.

1. Matlacha on Shoreview

1.4 km from Matlacha Isles

Francisco

CA $189 total

includes taxes & fees

Nov 10 - Nov 11

A beachside area with colorful beach houses, a dock, and a sandy beach.

2. Matlacha Tiny Village

2.5 km from Matlacha Isles

Shannon

CA $314 total

includes taxes & fees

Nov 10 - Nov 11

A turquoise building with a red door, surrounded by potted plants and flowers.

3. Angler's Inn

2.5 km from Matlacha Isles

Paul

CA $245 total

includes taxes & fees

Nov 10 - Nov 11

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

4. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Downtown Cape Coral, 13.6 km from Matlacha Isles

Sherri

CA $159 total

includes taxes & fees

Nov 15 - Nov 16

A modern dining area with a central island, multiple tables, and chairs.

5. Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers

Hancock, 11.5 km from Matlacha Isles

Mauricio

CA $173 total

includes taxes & fees

Nov 22 - Nov 23

A modern hotel lobby with a seating area, a reception desk, and a dining area.

6. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Caloosahatchee, 12.3 km from Matlacha Isles

Joseph E.

CA $151 total

includes taxes & fees

Dec 10 - Dec 11

A balcony with a table and chairs, large windows, and a view of the sea.

7. The Westin Cape Coral Resort At Marina Village

Pelican, 12.3 km from Matlacha Isles

Charles

CA $293 total

includes taxes & fees

Nov 16 - Nov 17

A modern kitchen area with a breakfast bar, fruit display, and a chalkboard menu.

8. Hampton Inn Fort Myers Downtown

17.6 km from Matlacha Isles

Donald

CA $167 total

includes taxes & fees

Nov 25 - Nov 26

A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

9. Residence Inn by Marriott Fort Myers Sanibel

18.1 km from Matlacha Isles

Lora

CA $161 total

includes taxes & fees

Nov 15 - Nov 16

A hotel with a modern design, featuring a prominent 'Best Western' sign, multiple parking spaces, and palm trees.

10. Best Western Fort Myers Inn & Suites

20.8 km from Matlacha Isles

Azael

CA $126 total

includes taxes & fees

Nov 11 - Nov 12

A hotel room with a bed, a desk, a chair, and a small table.

11. SpringHill Suites by Marriott Fort Myers Airport

27.1 km from Matlacha Isles

Jon B.

CA $139 total

includes taxes & fees

Nov 29 - Nov 30

A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

12. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

18.3 km from Matlacha Isles

Samantha

CA $126 total

includes taxes & fees

Nov 23 - Nov 24

A nighttime view of a bar with a pool in front.

13. Dolphin Key Resort

Caloosahatchee, 13.7 km from Matlacha Isles

DANIEL

CA $148 total

includes taxes & fees

Nov 22 - Nov 23

A modern hotel lobby with a reception desk, seating area, and a dining section.

14. Holiday Inn Express & Suites Fort Myers Airport by IHG

29 km from Matlacha Isles

Brian

CA $170 total

includes taxes & fees

Nov 13 - Nov 14

15. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

20.7 km from Matlacha Isles

Rick

CA $137 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

16. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

19.8 km from Matlacha Isles

Chris

CA $153 total

includes taxes & fees

Nov 17 - Nov 18

A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

17. Marriott Sanibel Harbour Resort & Spa

17.2 km from Matlacha Isles

Yunior

CA $401 total

includes taxes & fees

Nov 23 - Nov 24

18. HomeTowne Studios by Red Roof Fort Myers

21.7 km from Matlacha Isles

Ashley

CA $102 total

includes taxes & fees

Nov 12 - Nov 13

An outdoor patio with wicker furniture, a fire feature, and string lights.

19. Hilton Garden Inn Ft Myers

18.9 km from Matlacha Isles

Celina

CA $159 total

includes taxes & fees

Nov 16 - Nov 17

A hotel room with a bed, desk, chair, and a balcony with a view of the sea.

20. Best Western Fort Myers Waterfront

Hancock, 16.7 km from Matlacha Isles

Lisa

CA $157 total

includes taxes & fees

Nov 23 - Nov 24

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Compare popular hotels in Matlacha Isles

Property	Star rating	Guest rating
Matlacha on Shoreview	2.0 star property	9.6 Exceptional 304 reviews	View
Angler's Inn	2.5 star property	9.4 Exceptional 336 reviews	View
Holiday Inn Express Cape Coral-Fort Myers Area by IHG	2.5 star property	9.4 Exceptional 1,754 reviews	View
Matlacha Tiny Village	3.0 star property	9.0 Wonderful 299 reviews	View
Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers	3.0 star property	9.4 Exceptional 916 reviews	View

Where to stay in Matlacha Isles

Find the best Matlacha Isles areas and neighborhoods for the activities you enjoy most.

A pier extending into the water with two gazebos at the end, under a sunset sky.

Pelican

If you're spending some time in Pelican, Tarpon Point and Chabad Jewish Center are top sights worth seeing.

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A coastal residential area with a marina, dense greenery, and high-rise buildings in the background.

Caloosahatchee

If you're spending some time in Caloosahatchee, Dolphin Marina and Cape Coral Yacht Club Beach are top sights worth seeing.

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A coastal cityscape with a beach, marina, and dense urban area.

Hancock

While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Pine Island Shopping Center.

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A sunset over a calm lake with a dock and palm trees.

Yacht Club

While there might not be top attractions in Yacht Club, you can explore the larger area and discover places like Cape Coral Yacht Club Beach and Dolphin Marina.

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A wooden pier extending into calm water with a clear sky and distant land.

Burnt Store

Though Burnt Store might not have many top sights, you can venture to the surrounding area to see attractions like Coral Oaks Golf Course and Burnt Store Marina.

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Top Matlacha Isles Hotel Reviews

Sanibel Island Beach Resort

10/10 Excellent

"We came to Sanibel for a mother-daughter getaway, and this resort was perfect. The staff is friendly and extremely helpful, the grounds are well-maintained, access to the beach could not have been easier, and the pool was clean and provided relaxation. I can't say enough about how clean our room was on arrival, and throughout our stay. The food at the cafe and restaurant was good too! Highly recommend!"